Electron Microscopy
This method allows us to see very small subcellular structures such as small vesicles with the great detail, allowing up to a 10 million-fold magnification. This is achieved by using electrons as the source of illumination instead of light. Samples must be specially prepared in order to utilize this form of microscopy. Typically, samples are coated in a heavy metal, which is able to reflect electrons. This way, we are able to construct an image based on how the electrons hit and reflect off the sample. This also means that we cannot image live samples with electron microscopy.